Thap1^{tm1c(EUCOMM)Hmgu}

The L1L2_Bact_P cassette was inserted at position 26650320 of Chromosome 8 upstream of exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by a splice acceptor site, a lacZ cassette and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 2 at position 26653288. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by removal of the lacZ cassette through flp-mediated recombination. (J:274428)