Log In|Sign Up
EN
CRISPR/Cas9 genome editing is used to introduce the R549X mutation, and the silent A548A mutation. The mouse Nek1 R549X mutation is equivalent to the human R550X NEK1 mutation and is associated with amyotrophic lateral sclerosis. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
