Homologous recombination with a targeting vector removed 365 bp containing Cd4 maturation enhancer E4m in Cd4 intron 1 and inserted a loxP site flanked neomycin resistance gene cassette upstream of neighboring Cd4 silencer S4 (Rr96). The neo cassette was removed through subsequent cre-mediated recombination. (J:267930)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129 x C57BL/6)F1
Targeted
Insertion, Intragenic deletion
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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