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CRISPR/Cas9 technology generated a 14 bp deletion at the 3' end of the 2.7-kb long exon 7, causing a frameshift and premature stop codon upstream of the cyclin box in exons 9-13. Exon 7 was targeted by guide RNA C40-TGAACTTGGCATGATAGCAC. Immunoprecipitation and Western blot analysis yielded no signal for either full-length or the predicted truncation product in adult testes extracts indicating a null or severe loss-of-function allele. (J:273304)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
