The targeting construct introduced floxed segment containing an inverted VH12 and Igh-driven B1-8. Cre-mediated recombination removed the neomycin resistance cassette and flips the expression cassettes such that VH12 is expressed. (J:271722)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count