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The mouse prion promoter drives the expression of the longest human tau (MAPT) isoform (4R2N) in which proline is replaced by a serine at amino acid position 301 of the protein (P301S). Seven lines were established (16, 50, 56, 72, 82, 96, and 100). Line 50 is the highest expressing line. Western blot analysis confirmed increased expression in the hippocampus and showed that human tau is phosphorylated at T181, S202/T205, S214, S262, and S396. (J:213361)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
