Log In|Sign Up
EN
This allele was generated through shotgun CRISPR/Cas9 editing using pooled sgRNAs that targeted each variable exon of the Pcdhg cluster and this allele was found to have small frameshift mutations disrupting the variable exons A12 and C5, a 9bp in-frame deletion in variable exon C4, which deletes amino acids 27-29 in the signal peptide, and a large 94 kb deletion spanning from variable exon A1 into A11, which leaves un-mutated only variable exons B8 and C3. (J:285314)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
