4930503L19Rik^{rs222904565-ins}

The C57BR/cdJ, C57L/J, 129P2/OlaHsd, 129S5SvEvBrd, 129S1/SvImJ, 129X1/SVJ, AKR/J, BALB/cJ, C3H/HeJ, CBA/J, PL/J, DBA/2J, SM/J, LP/J, ST/bJ, PWK/PhJ, RF/J, SPRET/EiJ and WSB/EiJ strains carry this allele. The molecular difference with other strains is the insertion of three base pairs (TTC) in the coding region of exon 4. This inserts a lysine between glutamic acid 235 and asparagine 236 in the encoded protein (UniProt Q8CB14), that confers resistance to urethane-induced pulmonary adenomas. This allele co-occurs with the 4930503L19Rikrs30066196-C, 4930503L19Rikrs216509331-T, 4930503L19Rikrs29775155-A, 4930503L19Rikrs30245983-G, and 4930503L19Rikrs241863237-del alleles to confer resistance. Through epistatic interaction with the Lrmprs13459098-C sensitive and Lrmprs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)