4930503L19Rik^{rs241863237-ins}

The SJL/J, NZB/BINJ, C57BL/10J, C57BL/6J, RIIIS/J, MA/MyJ, SWR/J and A/J strains carry this allele. The molecular difference with other strains is the insertion of nine base pairs (GGCGCTGTC) in the coding region of exon 3. This insert adds three codons, GAC-AGC-GCC coding for Asp-Ser-Ala (amino-acids 32-34 in UniProt Q8CB14), that confer sensitivity to urethane-induced pulmonary adenomas. This allele co-occurs with the 4930503L19Rikrs30066196-T, 4930503L19Rikrs216509331-G, 4930503L19Rikrs29775155-C, 4930503L19Rikrs30245983-A, and 4930503L19Rikrs222904565-del alleles to confer sensitivity. Through epistatic interaction with the Lrmprs13459098-C sensitive and Lrmprs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)