4930503L19Rik^rs30066196-T

This T variant of the SNP is found in exon 3 (the first coding exon) of the gene in the Par2 (pulmonary adenoma resistance 2) region in the SJL/J, NZB/BINJ, C57BL/10J, C57BL/6J, RIIIS/J, MA/MyJ, O20, SWR/J, and A/J strains and creates a glutamine codon (CAA) at position 13 (UniProt Q8CB14). It co-occurs with the 4930503L19Rikrs29775155-C, 4930503L19Rikrs216509331-G, 4930503L19Rikrs30245983-A, 4930503L19Rikrs241863237-ins, and 4930503L19Rikrs222904565-del alleles to confer sensitivity to urethane-induced pulmonary adenomas. Through epistatic interaction with the Lrmprs13459098-C sensitive and Lrmprs13459098-T resistant alleles in the pulmonary adenoma susceptibility 1 (Pas1) region these Par2 alleles modulate the sensitivity or resistance of the two Pas1 alleles. (J:150946)