Nlrp3^m12Btlr

ENU-mutagenesis induced an A to T transversion at base pair 59,558,448 (v38) on chromosome 11, or base pair 16,880 in the GenBank genomic region NC_000077. The mutation corresponds to residue 2,781 in the mRNA sequence NM_145827 within exon 7 of 10 total exons. The mutated nucleotide is indicated in red. The mutation results in a histidine to leucine substitution at position 852 (H852L) in the NLRP3 protein. (J:272150)