This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTCCAGGACAAAGATCACCA and GCTGCTTTGTGGTTTTATAT, which resulted in a 1406 bp deletion beginning at Chromosome 3 position 90,541,810 bp and ending after 90,543,215 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000637998 and ENSMUSE00000637995 (exons 2 and 3) and 440 bp of flanking intronic sequence including the splice acceptor translation start and is predicted to result in a null allele. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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