A targeting vector was designed to replace the entire 13.3 kb of the gene, including the entire coding sequence, with a phosphoglycerate kinase-driven neomycin resistance gene. Homologous recombination results in deletion of a segment of chromosome 10 extending from 102,854,233-102,862,254 (GRCh38/hg38). (J:271219)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count