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The first loxP was inserted into intron 14, and the second loxP together with neomycin-resistant gene flanked by FRT sites was inserted into intron 16. The Neo-cassette was removed using FLPeR mice, leaving exons 15 and 16 floxed. The 2 exons encode part of Tie1 intracellular domain (ICD). (J:271100)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
