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The targeting construct inserted into the locus a loxP flanked neomycin/STOP cassette and human GNA11 cDNA with a glutamine to leucine substitution at amino acid 209 (Q209L). Upon cre-mediated recombination of the loxP, the neo-STOP cassette is excised and the mutant is expressed. (J:271104)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
