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CRISPR/cas9 endonuclease-mediated NHEJ genome editing is used to delete exons 2 through 7 resulting in a frameshift mutation and introducing a premature stop codon in exon 7. qPCR analysis confirmed the absence of mRNA expression in liver, lung, and spleen tissue of homozygous mutant mice. (J:267987)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
