Log In|Sign Up
EN
CRISPR/Cas9 technology introduced loxP sites flanking exon 3 and also moved two bases from the 5' end of exon 4 to the 3' end of exon 3 to enable a frameshift upon conditional deletion of exon 3. Sequencing confirmed that the engineered exon-3 and exon-4 junctions are canonically spliced to produce an mRNA that is identical to the mRNA from wild-type mice. mRNA levels are comparable between homozygotes and wild-type mice. (J:271070)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
