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Three mutations, a leucine to alanine at amino acid 1298, an arginine to asparagine at amino acid 1300, and a serine to aspartate at amino acid 1303 (L1298A/R1300N/S1303D), were introduced in the CTD2B sub-region, and a loxP-flanked neomycin phosphotransferase gene driven by a compound phosphoglycerate kinase (PGK) and EM7 promoter was inserted. The mutations abrogate CaMKII binding to Grin2b. Cre-mediated recombination removed the neo cassette. (J:271055)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
