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A targeting vector containing IRES-cre coding sequence followed by a polyadenylation signal sequence, and a FRT site flanked PGK-neo cassette was inserted immediately following the stop codon in exon 21 of the targeted Kit gene. The construct was electroporated into embryonic stem (ES) cells. Chimeric mice were generated by aggregating correctly targeted ES cells by tetraploid complementation. The resulting chimeric animals were tested for germline transmission. (J:245913)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
