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The Syrian hamster prion protein promoter drives the expression the guinea pig prion protein open reading frame cDNA in the brain (cos.Tet vector was used to generate the transagene). Three lines, 23441, 23447, and 23454 were generated. This line expresses the protein at approximately 2.5-fold the levels in wild-type mice and are estimated to overexpress at approximately 3-fold the level found in guinea pigs. (J:236012)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
