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The human beta globin cluster is modified such that the locus control region (LCR) consisting of 4 DNAse I hypersensitive site (HS4-1) is inserted upstream of HBG2, HBG1, and the HBBP1 pseudogene. Founder line 1352 was established. Expression of the HBG2 gene is 3-7 fold higher than the HBG1 gene in embryonic and fetal erythroid cells. (J:39123)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
