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CRISPR/Cas9 mutagenesis was used to create mutations in codon 95 to alter the codon to encode an alanine instead of a tryptophan (W95A). This mutation was shown in vitro to abolish interactions with Cnot7 and Cnot8. An altered protein is detectable in oocytes derived from mutant mice. (J:245369)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
