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This transgene consists of a hemagglutinin (HA)-tagged fragment of Ncoa6 encoding amino acids 849-929 under the control of the chicken beta-actin promoter linked to a human cytomegalovirus immediate-early enhancer (CAG). This Ncoa6 fragment encompasses the N-terminal LXXLL motif (called DN1) and has a strong dominant negative effect on transactivation by retinoid and other nuclear receptors. This line shows transgene expression in the eye, heart, and brain. (J:80609)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
