An frt-flanked neo cassette was inserted upstream of two exons encoding a portion of the cofactor binding domain (amino acids 117-187). Additionally, the inserted neo cassette and the two exons were flanked by a single loxP sites. Flp mediated recombination removed the neo cassette. (J:83623, J:269584)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count