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The transgene contains the cDNA for a mutated form of the rat cAMP responsive element binding protein 1 downstream of the tetracycline-responsive element. The cDNA has A>G and A>C point mutations changing codon 304 (p.K304A) from lysine to alanine, thereby inactivating or severely reducing the peptide's capacity to bind to the cAMP response element (CRE) on the DNA, without affecting dimerization with wild-type peptide. The cDNA sequence had been previously modified to change codons Cys300, Cys310, and Cys337 to serine to improve solubility. (J:76362)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
