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This transgene consists of the chicken beta-actin (CX1) promoter, followed by a loxP-flanked EGFP gene including a stop codon, and a pore rat Kcnj8 dominant negative mutant in which glycine-phenylalanine-glycine was mutated to three alanines. EGFP is ubiquitously expressed unless cre-recombinase is expressed which excises the EGFP and results in expression of the mutant Kcnj8. Three lines were generated but only a single line was selected for further study. (J:134852)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
