A construct, containing an FRT flanked cassette, encoding a splice-acceptor site, lacZ gene and neo resistance gene, and a loxP site, was inserted in intron 3 and a second loxP site was inserted in intron 4 via homologous recombination. Recombinase mediated recombination removed the FRT flanked cassette and exon 4. (J:268910)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count