The targeting construct contains a loxP site upstream of exon 1 and a loxP-flanked neomycin selection cassette downstream of exon 4. Cre-mediated recombination removed the floxed neo cassette. (J:268957)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count