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A hamster PrP promoter drives expression of a mutant form of human SNCA (A30P). Two mouse lines were generated, Tg5093 and Tg5102). The highest expressing line (Tg5093) had 15-fold transgenic brain alpha-synuclein A30P expression and age-related motor dysfunction, and was characterized in detail. (J:102796)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
