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The targeting vector contains a loxP site upstream of exon 2, a FRT-flanked neomycin selection cassette downstream of exon 2 followed by a loxP 2272 sequence, an inverted mutant exon 2 carrying the serine to phenylalanine (S34F) missense mutation, a loxP site and another loxP2272 sequence. Flp-mediated recombination removed the neomycin cassette. The mutant exon 2 replaces the wild-type exon after cre-mediated recombination. (J:267082)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
