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A point mutation in the 3' DNA adjacent to pre-mir-16-1 region in NZB. A T-to-A mutation at base 61,631,880 (GRCm38) on the sense strand of chr 14 in the NZB/BlNJ strain is not present in DBA/2J, C57BL/6J, SJL/J, NZW, BALB/c, and NOD/SCID. Levels of miR-16 were decreased in NZB lymphoid tissue. (J:124364)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
