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A proximal loxP site and FRT-flanked PGK-neomycin cassette were inserted in intron 41, a distal loxP site was inserted in intron 42, and G2019S mutation was inserted in exon 41 via homologous recombination. Flp mediated recombination removed the neo cassette. The expressed protein is resilient to kinase inhibition. (J:147112, J:268603)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
