Log In|Sign Up
EN
The first two exons common to all three major isoforms (A,B,C) were flanked by loxP sites and a neomycin selection cassette with a loxP at the N-terminus was inserted upstream of the floxed exons. Cre-mediated recombination excised the neomycin cassette generating a conditional allele. Removal of the two floxed exons eliminates the expression of the growth inhibitory Nogo-66 amino acid loop shared by all three isoforms and is predicted to result in a null for the C isoform and severe hypomorph for the A and B isoforms. (J:268491)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
