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The CRISPR/Cas9 system and sgRNA 5'-ACAGTGAGATTGAGCGGCGC-3' was used to generate the mice. The CRISPR/Cas9 system generated a one-base pair replacement at c.373T>C (NM_007488.3). The mutation results in an arginine to cysteine change at amino acid 74 (p.R74C). (J:268298)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
