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Exon 10 was replaced with one containing a point mutation resulting in a tyrosine to phenylalanine change at amino acid 416 (Y416F) and exon 11 was flanked by loxP sites. In addition, a neomycin resistance cassette flanked by FRT sites was inserted upstream of exon 11. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination deleted exon 11 and abrogates STAT and ERK signaling and leads to a shortened intracellular domain with 14 alternative amino acids coded by the former intron 11 until translation is stopped by a new stop codon. (J:268135)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
