This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GTGTCCTTCCACTACTTGGG and GACACAGTATGCCTTCAGAC, which resulted in a 2235 bp deletion beginning at Chromosome 10 position 79,964,652 bp and ending after 79,966,886 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000314370-ENSMUSE00000314328 (exons 3-8) and 1458 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 108 removing 258 amino acids and to retain the last 65 amino acids before the stop. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count