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CRISPR/Cas9 techinology using guide RNA (CCCCAGCCTGCCACATCAGACGG), SpCas9, and a 127 bp single-stranded mutagenic oligo introduce a c.1876 G to A transversion (NM_004456.4). The resultant GTG to ATG bp (V626M aa) substitution in exon 16 of the gene is confirmed through sequencing. (J:267184)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
