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This allele was created by crossing mice carying the Usp29tm1Jkim allele with cre-expressing mice (Tg(Zp3-cre)93Knw). Usp29tm1Jkim was created as follows: a loxP site was inserted into intron 1 of Peg3 upstream of the Peg3-DMR (differentially methylated region). A neomycin resistance gene cassette (in the same transcriptional direction as the targeted gene) and a second loxP site were inserted into intron 1 of downstream neigbor Usp29, with which Peg3 shares a bidirectional promoter. Cre-mediated recombination deletes the ~4 kb Peg3-DMR region including the first exons of Peg3 and Usp29. (J:259918)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
