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This allele from project TCPR1205 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of CTACCCGTGCCACATCCTTG and GGCACTGTGTCCCGCTGCGA targeting the 5' side and CCATTCAGCATGGGTCCCGT and ATGCGTATTATGACCCGCCT targeting the 3' side of a critical exon. This resulted in a 24-bp indel Chr14: 55543596 to 55543619 and 252-bp del Chr14: 55543654 to 55543905, p.(A122_V129del, S142Hfs*21 resulting in a frameshift mutation in all annotated full length protein-coding transcripts (GRCm38). (J:265051)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
