Log In|Sign Up
EN
A floxed puromycin with a splice acceptor, four SV40 polyadenylation sequences and splice donor was inserted upstream of exon 8. Exon 9 was modified with a C to G point mutation to induce the amino acid substitution of arginine for proline at position 286 (P286R). This mutation is present in human cancers and leads to error-prone DNA replication. (J:266324)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
