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A FRT site flanked targeting vector, with a loxP site at the downstream end and containing a PGK-neo selection cassette was utilized in the construction of this mutant. This selection cassette was inserted downstream of exon I (also called exon 2, when the first non-coding exon is included in the numbering scheme) of the targeted gene, and another loxP site was inserted upstream of exon III (also called exon 4, when the first non-coding exon is included in the numbering scheme). The PGK-neo selection cassette was removed by Flp-recombinase mediated excision. Exon II is flanked by loxP sites. Cre-mediated recombination removed exon II. (J:266012)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
