Log In|Sign Up
EN
CRISPR/Cas9 technology is used to delete exon 2 of Bglap through exon 4 of Bglap2 (6.8 kb). This deletion leaves the first 4 amino acids of exon 2 of Bglap intact followed by a 5bp insertion and a portion of exon 4 of Bglap2. The mutation is predicted to create a reading frame shift after the 25th amino acid and a termination codon 17 residues further downstream. Mature protein is undetectable in homozygous animals. (J:289623)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
