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Seven direct repeats of the tetracycline operator sequence drive the inducible expression of the human EGFR with the T790M mutation and deletion of exon 19 (del E746_A750). Mice with this transgene that express the tetracycline transactivator (tTA) or reverse transactivator (rtTA) under the control of a tissue-specific promoter can be induced to express the mutant gene in tissues or cell types of interest by administration/withdrawal of doxycycline. (J:156440)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
