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The CAG promotor, a loxP-flanked STOP cassette (LSL) and the human EGFR cDNA with the L858R, the T790M, and the C797S mutations were inserted into the locus. Upon cre-mediated recombination, the STOP cassette is excised promoting expression of the mutant EGFR. (J:235747)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
