A loxP site was inserted 216 bp downstream of exon 12 and a PGK promoter-driven neomycin resistance cassette flanked by frt-sites and preceded by another loxP site were inserted 265 bp upstream of exon 12. The selection cassette was removed via Flp-mediated recombination leaving exon 12 foxed. (J:266630)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count