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The targeting vector is designed to have (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), an FRT site, a loxP site, a transcriptional/translational STOP cassette (with stop codons in all 3 reading frames and a triple polyA signal), a second loxP site, a cDNA sequence encoding the mouse C9orf72 member of C9orf72-SMCR8 complex (C9orf72), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE), a BGH polyA signal, a second FRT site and a neo cassette. The construct is inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
