Log In|Sign Up
EN
This transgene consists of the rat Kcnj8 cDNA with a glycine to aspartate substitution at amino acid 343 (Gly343Asp), rendering ATP-insensitivity, under the control of the CX1 promoter which contains the chicken beta-actin promoter followed by the enhanced green fluorescent protein coding region (including a stop codon) flanked by loxP sites. EGFP is ubiquitously expressed unless cre-recombinase is expressed which excises the EGFP and results in expression of the mutant Kcnj8. Lines 9 and 10 are the high expressing lines, with line 9 entered as the representative line. (J:202037)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
