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This transgene, comprising the 310 kb human chr 11 YAC Y589 (from ICI library), retrofitted with a conditional centromere, was microinjected into pronuclei of B6CBA embryos. The YAC spans 160 kb upstream and 150 kb downstream of PAX6 promoter P1, a region that includes the SGL but not the SIMO breakpoints associated with cases of familial aniridia. Four transgenic lines were established, with line 3 carying two downstream truncated copies (lacking the last ~100 kb) of the YAC in head-to-head orientation. (J:265823)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
