Cr2^{tm1(CR2,CR1)How}

A targeting vector containing human CR2, complement C3d receptor 2, gene sequence with an attB-PGKneo-attP cassette in intron 19, followed by the intergenic region between the human CR2 and CR1 genes, and human CR1, complement C3b/C4b receptor 1 (Knops blood group), gene sequence (with a loxP site inserted into intron 3, a FRT site inserted into intron 12, and loxP and FRT sites inserted into intron 20), was inserted at the ATG initiation codon of the mouse Cr2 gene. The CR1 gene sequence has exons 4 through 20 flanked by loxP sites and exon 13 through 20 flanked by FRT sites. Recombination removed the selection cassette. (J:296605)