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Pronuclei of fertilized oocytes were injected with a plasmid containing 7.6 kb of upstream sequence from the mouse whey acidic protein gene driving expression of a secreted form of human placental alkaline phosphatase lacking the membrane anchoring domain (SEAP, ClonTech), which serves as a promoter/enhancer reporter. Mice of founder line p1435 carry 60 tandem copies of the transgene. No expression is detected in mammary gland; high ectopic expression occurs in kidney, muscle, and lung. (J:82809)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
